Searching for New Natural Inhibitors of Acetylcholinesterase Enzyme

New Acetylcholinesterase Inhibitors for Alzheimer's Disease

Acetylcholinesterase (AChE) remains a highly viable target for the symptomatic improvement in Alzheimer's disease (AD) because cholinergic deficit is a consistent and early finding in AD. The treatment approach of inhibiting peripheral AchE for myasthenia gravis had effectively proven that AchE inhibition was a reachable therapeutic target. Subsequently tacrine, donepezil, rivastigmine, and gal...

Natural sesquiterpen lactones as acetylcholinesterase inhibitors.

Background and the purpose of the study: The amount of elder people who suffer from Alzheimer disease is continuously increasing every year. Cholinesterase inhibitors have shown to be effective in alleviating the symptoms of the disease, thus opening a field of research for these treatments. Herbal products, owning a reputation as effective agents in many biological studies are now drawing atte...

novel coumarin analogues: as new acetylcholinesterase inhibitors

new pantacyclic tacrines as potent acetylcholinesterase inhibitors

Natural Inhibitors of the Aromatase Enzyme*

The results of three years of search for natural aromatase inhibitors will be presented. Estrogen biosynthesis is catalyzed by the aromatase enzyme complex. This complex if made up of a member of the cytochrome P450 superfamily of enzymes known as cytochrome P450 aromatase (P450arom, produced by the CYP19 gene). Associated with this enzyme one finds the flavoprotein NADPH cytochrome P450 reduct...